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Thorne’s 5-MTHF includes an active ingredient that is tissue-ready and in its most bioavailable form for better absorption. In conjunction with vitamin B12, 5-MTHF functions as a methyl-group donor, which facilitates the conversion of the undersirable amino acid homocysteine to the more desirable methionine.* Methyl-group donation is vital to many necessary biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA